科研项目： |
1.Bcl-2与SIRT3通过整合细胞代谢-凋亡参与卵巢癌耐药机制的研究,国家自然科学基金(81472419) 2015.01.01-2018.12.31, 78.0万,负责人 2. BH3-only蛋白模拟物S1通过内质网应激信号网络逆转人卵巢癌细胞耐药机制的研究,国家自然科学基金(81272876) 2013.01.01-2015.12.31, 72.0万,负责人 3.至纳米级鹿骨粉开发及其生物相容性和生物效能研究,省科技厅中药办(20120913) 2012.01-2014.12, 18.0万,负责人 4. BH3-only蛋白模拟小分子化合物S1调控内质网应激-自噬途径机制的研究,国家自然科学基金(81141099) 2012.01.01- 2012.12.31, 10.0万,负责人 5.新药“三参维心胶囊”一期临床研究,省计委, 2011.06-2013.06, 10.0万,负责人 6.人/大鼠分子病理诊断技术的开发,横向协作课题（2012220101000660） 2011.11-2012.1, 10.0万,负责人 7.前列腺癌早期发现早期诊断, 国际合作 48.0万,负责人 8.新药“三参维心胶囊”的研制开发,吉林省发改委, 50.0万,负责人 |
学术论文： |
发表文章（近三年，10篇以内） 1, Xiang XY, Kang JS, Yang XC, Su J, Wu Y, Yan XY, Xue YN, Xu Y, Liu YH, Yu CY, Zhang ZC, Sun LK1*, SIRT3 participates in glucose metabolism interruption and apoptosis induced by BH3 mimetic S1 in ovarian cancer cells, Int J Oncol, 2016 Aug;49(2):773-84 2, Xiang XY, Yang XC, Su J, Kang JS, Wu Y, Xue YN, Dong YT, Sun LK*, Inhibition of autophagic flux by ROS promotes apoptosis during DTT-induced ER/oxidative stress in HeLa cells, Oncol Rep, 2016 Jun;35(6):3471-9 3, Zhou, XL; Yu, SS ; Su, J ; Sun, LK *, Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases , Int. J. Mol. Sci., 2016, 17(3), 340 4, Shen L, Wen N, Xia M, Zhang YU, Liu W, Xu YE*, Sun L*., Calcium efflux from the endoplasmic reticulum regulates cisplatin-induced apoptosis in human cervical cancer HeLa cells, Oncol Lett., 2016 Apr;11(4):2411-2419. 5, Li X, Su J1, Xia M, Li H, Xu Y, Ma C, Ma L, Kang J, Yu H, Zhang Z, Sun L., Caspase-mediated cleavage of Beclin1 inhibits autophagy and promotes apoptosis induced by S1 in human ovarian cancer SKOV3 cells, Apoptosis, 2016 Feb;21(2):225-38 6, Ma, LW ; Xu, Y ; Su, J ; Yu, HM ; Kang, JS ; Li, HY ; Li, XN ; Xie, Q ; Yu, CY ; Sun, LK *; Li, Y *, Autophagic flux promotes cisplatin resistance in human ovarian carcinoma cells through ATP-mediated lysosomal function , Int J Oncol, 2015 Nov; 47(5):1890-900 7, Gu, S ; Yang, XC ; Xiang, XY ; Wu, Y ; Zhang, Y ; Yan, XY ; Xue, YN ; Sun, LK * ; Shao, GG *, Sanguinarine-induced apoptosis in lung adenocarcinoma cells is dependent on reactive oxygen species production and endoplasmic reticulum stress , Oncol Rep., 2015 Aug; 34(2):913-9 8, Fan Z, Yu H, Cui N, Kong X, Liu X, Chang Y, Wu Y, Sun L*, Wang G*., ABT737 enhances cholangiocarcinoma sensitivity to cisplatin through regulation of mitochondrial dynamics, Exp Cell Res, 2015 Jul 1;335(1):68-81 9, Su J, Liu F, Xia M, Xu Y, Li X, Kang J, Li Y, Sun L., p62 participates in the inhibition of NF-κB signaling and apoptosis induced by sulfasalazine in human glioma U251 cells, Oncol Rep, 2015 Jul;34(1):235-43 10, Yang X, Xiang X, Xia M, Su J, Wu Y, Shen L, Xu Y, Sun L., Inhibition of JNK3 Promotes Apoptosis Induced by BH3 Mimetic S1 in Chemoresistant Human Ovarian Cancer Cells, Anat Rec (Hoboken), 2015 Feb;298(2):386-95 |
